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Invitrogen™ CNOT7 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA531139
Description
Recommended positive controls: U87-MG. Predicted reactivity: Human (99%), Mouse (99%), Rat (99%), Zebrafish (94%), Xenopus laevis (95%), Chicken (99%), Rhesus Monkey (99%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CNOT7 (CCR4-NOT transcription complex subunit 7) has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. CNOT7 is a catalytic component of the CCR4-NOT complex, which is one of the major cellular mRNA deadenylases, and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation. During miRNA-mediated repression, the complex seems to act as a transcriptional repressor during translational initiation, as well. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT7 associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Specifications
CNOT7 | |
Polyclonal | |
Unconjugated | |
CNOT7 | |
AU022737; BTG1-binding factor 1; CAF1; CAF-1; Caf1a; carbon catabolite repressor protein (CCR4)-associative factor 1; catabolite repressor protein (CCR4)-associative factor 1; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 7; CCR4-NOT transcription complex subunit-like protein; CCR4-NOT transcription complex, subunit 7; CNOT7; fd59c07; fj07d05; hCAF-1; hypothetical protein LOC508055; Pop2; POP2 homolog; wu:fd59c07; wu:fj07d05; zgc:153168 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
29883 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
0.84 mg/mL | |
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
Q9UIV1 | |
CNOT7 | |
Recombinant protein fragment corresponding to a region within amino acids 1 and 150 of Human CNOT7. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
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