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Invitrogen™ CNOT7 Polyclonal Antibody
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Catalog No. PIPA540570
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100 μL
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PIPA540570 100 μL
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Catalog No. PIPA540570 Supplier Invitrogen™ Supplier No. PA540570
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Description

Rabbit Polyclonal Antibody

Peptide sequence: LDFFEILRLF FPVIYDVKYL MKSCKNLKGG LQEVAEQLEL ERIGPQHQAG Sequence homology: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 83%; Zebrafish: 100%.

CNOT7 (CCR4-NOT transcription complex subunit 7) has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. CNOT7 is a catalytic component of the CCR4-NOT complex, which is one of the major cellular mRNA deadenylases, and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation. During miRNA-mediated repression, the complex seems to act as a transcriptional repressor during translational initiation, as well. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT7 associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CNOT7
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene CNOT7
Gene Accession No. Q9UIV1
Gene Alias AU022737; BTG1-binding factor 1; CAF1; CAF-1; Caf1a; carbon catabolite repressor protein (CCR4)-associative factor 1; catabolite repressor protein (CCR4)-associative factor 1; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 7; CCR4-NOT transcription complex subunit-like protein; CCR4-NOT transcription complex, subunit 7; CNOT7; fd59c07; fj07d05; hCAF-1; hypothetical protein LOC508055; Pop2; POP2 homolog; wu:fd59c07; wu:fj07d05; zgc:153168
Gene Symbols CNOT7
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human CNOT7.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29883
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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