Invitrogen™ CNOT7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA540570

Catalog No. PIPA540570

Description

Peptide sequence: LDFFEILRLF FPVIYDVKYL MKSCKNLKGG LQEVAEQLEL ERIGPQHQAG Sequence homology: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 83%; Zebrafish: 100%.

CNOT7 (CCR4-NOT transcription complex subunit 7) has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. CNOT7 is a catalytic component of the CCR4-NOT complex, which is one of the major cellular mRNA deadenylases, and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation. During miRNA-mediated repression, the complex seems to act as a transcriptional repressor during translational initiation, as well. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT7 associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Specifications

• Antigen: CNOT7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CNOT7
• Gene Alias: AU022737; BTG1-binding factor 1; CAF1; CAF-1; Caf1a; carbon catabolite repressor protein (CCR4)-associative factor 1; catabolite repressor protein (CCR4)-associative factor 1; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 7; CCR4-NOT transcription complex subunit-like protein; CCR4-NOT transcription complex, subunit 7; CNOT7; fd59c07; fj07d05; hCAF-1; hypothetical protein LOC508055; Pop2; POP2 homolog; wu:fd59c07; wu:fj07d05; zgc:153168
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29883
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9UIV1
• Gene Symbols: CNOT7
• Immunogen: Synthetic peptide directed towards the middle region of human CNOT7.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG