Invitrogen™ CNTF Monoclonal Antibody (34738)

Catalog No.	Quantity
PIMA523730	500 μg

Catalog No. PIMA523730 Supplier Invitrogen™ Supplier No. MA523730

Description

Mouse Monoclonal Antibody

In sandwich ELISAs, less than 3% cross-reactivity with recombinant human CNTF is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <1.0 EU per 1 μg of the antibody by the LAL method.

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.

Specifications

• Antigen: CNTF
• Applications: ELISA, Neutralization
• Classification: Monoclonal
• Clone: 34738
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: CNTF
• Gene Accession No.: P20294
• Gene Alias: AI429687; Ciliary neurotrophic factor; ciliary neurotropic factor; Cntf; HCNTF; H-CNTF
• Gene Symbols: CNTF
• Host Species: Mouse
• Immunogen: E. coli-derived recombinant rat CNTF Ala2-Met200.
• Purification Method: Protein A/G
• Quantity: 500 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 25707
• Target Species: Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2b