Invitrogen™ CNTFR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596193

Catalog No. PIPA596193

Description

Immunogen sequence: FHRDSWHLRH QVLLHVGLPP REPVLSCRSN TYPKGFYCSW HLPTPTYIPN TFNVTVLHGS KIMVCEKDPA LKNRCHIRYM HLFSTIKYKV SISVSNALGH NATAITFDEF TIVKPDPPEN VVARPVPSNP RRLEVTWQTP STWPDPESFP LKFFLRYRPL ILDQWQHVEL SDGTAHTITD AYAGKEYIIQ VAAKDNEIGT WSDWSVAAHA TPWTEEPRHL TTEAQAAETT TSTTSSLAPP PTTKICDPGE LGS Positive Samples: U-87MG, HeLa, Mouse brain, Mouse heart, Rat testis; Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor.

This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.

Specifications

• Antigen: CNTFR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cntfr
• Gene Alias: ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor alpha; ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; Cntfr; CNTFR alpha; CNTFRALPHA; CNTFR-alpha; MGC1774
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1271, 12804, 313173
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.91 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O88507, P26992, Q08406
• Gene Symbols: Cntfr
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 90-342 of human CNTFR (NP_6716931).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG