Invitrogen™ CNTFR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119975

Catalog No. PIPA5119975

Description

Positive Control: Mouse cerebellum tissue lysate, rat brain tissue lysate, NIH/3T3 cell lysate, human fetal skeletal muscle tissue, mouse heart tissue, Hela. Subcellular Location: Cell membrane.

This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.

Specifications

• Antigen: CNTFR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cntfr
• Gene Alias: ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor alpha; ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; Cntfr; CNTFR alpha; CNTFRALPHA; CNTFR-alpha; MGC1774
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1271, 12804, 313173
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O88507, P26992, Q08406
• Gene Symbols: Cntfr
• Immunogen: Synthetic peptide within human CNTFR aa 201-250.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG