Invitrogen™ CNTNAP1 Monoclonal Antibody (A2D2)

Catalog No.	Quantity
PIMA542405	100 μL

Catalog No. PIMA542405 Supplier Invitrogen™ Supplier No. MA542405

Description

Mouse Monoclonal Antibody

Positive Control: Human kidney tissue, mouse kidney tissue, SH-SY5Y. Subcellular Location: Membrane, paranodal septate junction.

CNTNAP1 was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. The gene product was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 381-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.

Specifications

• Antigen: CNTNAP1
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: A2D2
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene: Cntnap1
• Gene Accession No.: O54991, P78357
• Gene Alias: AI841080; Caspr; caspr1; CNTNAP; CNTNAP1; contactin associated protein 1; contactin associated protein-like 1; contactin-associated protein 1; LOW QUALITY PROTEIN: contactin-associated protein 1; MHDNIV; NCP1; neurexin 4; neurexin 4 (contactin associated protein); neurexin IV; Neurexin-4; NRXN4; p190; paranodin; shm
• Gene Symbols: Cntnap1
• Host Species: Mouse
• Immunogen: Recombinant protein within human Caspr aa 1100-1300.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 53321, 8506
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1