Invitrogen™ CNTNAP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552853

Catalog No. PIPA552853

Description

Immunogen sequence: MRLNGVTLNL EGRANASEGT SPNCTGHCAH PRLPCFHGGR CVERYSYYTC DCDLTAFDGP YCNHDIGGFF EPGTWMRYNL QSALRSAARE FSHMLSRPVP GYEPGYIPGY DTPGY Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

CNTNAP1 was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. The gene product was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 381-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.

Specifications

• Antigen: CNTNAP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cntnap1
• Gene Alias: AI841080; Caspr; caspr1; CNTNAP; CNTNAP1; contactin associated protein 1; contactin associated protein-like 1; contactin-associated protein 1; LOW QUALITY PROTEIN: contactin-associated protein 1; MHDNIV; NCP1; neurexin 4; neurexin 4 (contactin associated protein); neurexin IV; Neurexin-4; NRXN4; p190; paranodin; shm
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8506
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P78357
• Gene Symbols: Cntnap1
• Immunogen: Recombinant protein corresponding to Human CNTNAP1. Recombinant protein control fragment (Product #RP-90100).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG