Invitrogen™ COCH Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA548475

Catalog No. PA548475

Description

Predicted to react with bovine based on sequence homology.

Cochlin is a secreted protein encoded by the coagulation factor C homology (COCH) gene, a cochlear gene. It constitutes 70% of the inner ear proteins and is classified into three glycosylated isoforms: p63s, p44s and p40. Cochlin contains an N-terminal LCCL domain and two von Willebrand factor A-like domains. Mutations in the COCH gene cause DFNA9, an autosomal dominant nonsyndromic auditory and vestibular dysfunction disorder, as a result of either an amino acid deletion in the LCCL domain or missense substitutions. Microfibrillar deposits accumulate in the inner ear of individuals with DFNA9 and these deposits may contain the Cochlin protein. Cochlin is a target antigen for autoimmune sensorineural hearing loss.

Specifications

• Antigen: COCH
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COCH
• Gene Alias: AW122937; coagulation factor C homolog (Limulus polyphemus); coagulation factor C homolog, cochlin (Limulus polyphemus); Coch; COCH5B2; COCH-5B2; Cochlin; D12H14S564E; DFNA9; PRO294; UNQ257; UNQ257/PRO294
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1690
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.48 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: O43405
• Gene Symbols: COCH
• Immunogen: KLH conjugated synthetic peptide between 399-428 amino acids from the Central region of human COCH.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG