Invitrogen™ Cofilin Monoclonal Antibody (GT217)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527737

Catalog No. PIMA527737

Description

Positive Control: 293T, A431, HeLa, HepG2, PC-12, Rat-2, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12 Predicted Reactivity: Pig (99%), Sheep (99%), Rhesus Monkey (99%), Bovine (99%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.

Specifications

• Antigen: Cofilin
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with 20% glycerol and no preservative; pH 7
• Gene Accession No.: P18760, P23528, P45592
• Gene Symbols: CFL1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Cofilin 1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: GT217
• Conjugate: Unconjugated
• Gene: CFL1
• Gene Alias: 18 kDa phosphoprotein; AA959946; CFL; Cfl1; CFL-1; Cof; COF1; cofilin; cofilin 1; cofilin 1 (non-muscle); cofilin 1, non-muscle; cofilin, non-muscle isoform; Cofilin1; Cofilin-1; cofilin-1-like protein; epididymis secretory protein Li 15; HEL-S-15; n-cofilin; p18
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1072, 12631, 29271
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid