Invitrogen™ COG2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530710

Catalog No. PIPA530710

Description

Recommended positive controls: Jurkat, Raji. Predicted reactivity: Mouse (94%), Rat (93%), Zebrafish (82%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The structure and function of the Golgi apparatus is controlled by a number of multi-protein complexes that are involved in glycosylation reactions and vesicular transport. The conserved oligomeric Golgi (COG) complex consists of three subcomplexes, termed LDLC, SEC34 and GTT (Golgi transport complex), all of which contain proteins necessary for proper Golgi operation. COG2 (conserved oligomeric Golgi complex subunit 2), also known as LDLC, is a 730 amino acid component of the COG complex. Localized to the cytoplasmic side of the Golgi apparatus, COG2 is required for proper Golgi morphology and function, specifically playing a role in Golgi ribbon formation and vesicular transport. Abnormal COG2 function may cause cell death, suggesting that COG2 is an important factor in cell viability.

Specifications

• Antigen: COG2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cog2
• Gene Alias: 1190002B08Rik; 2700012E02Rik; brefeldin A-sensitive, peripheral Golgi protein; C86089; COG 2; COG complex subunit 2; COG2; Component of oligomeric Golgi complex 2; conserved oligomeric Golgi complex protein 2; conserved oligomeric Golgi complex subunit 2; LDLC; low density lipoprotein receptor defect C complementing; low density lipoprotein receptor defect C-complementing protein; Transcript ch4822
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22796
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.45 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q14746
• Gene Symbols: Cog2
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human COG2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov