Invitrogen™ COL11A1 Polyclonal Antibody

Catalog No.	Quantity
PIPA536227	100 μL

Catalog No. PIPA536227 Supplier Invitrogen™ Supplier No. PA536227

Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 181 kDa. Purity is >95% by SDS-PAGE.

Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family. Collagen Type XI is thought to play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This protein forms trimers composed of three different chains: a 1(XI), a 2(XI), and a 3(XI). a 3(XI) is a post-translational modification of a 1(II). a 1(V) can also be found instead of a 3(XI). Collagen Type XI has three named isoforms (A,B,C) and additional isoforms seem to exist, stemming from alternative usage of exon IIA or exon IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon. Collagen Type XI contains a single collagen binding TSP N-terminal (TSPN) domain. Collagen Type XI is expressed in cartilage, placenta and some tumor or virally transformed cell lines. Isoform expression can be tissue specific. Defects in the COL11A gene are the cause of Stickler syndrome type 2 (STL2), or beaded vitreous type, due to the presence of irregularly thickened fiber bundles throughout vitreous cavity.

Specifications

• Antigen: COL11A1
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene: COL11A1
• Gene Accession No.: P12107, Q61245
• Gene Alias: a1(XI) collagen; C530001D20Rik; cho; chondrodysplasia; CO11A1; COBA1; COL11A1; COLL6; Collagen alpha 1; collagen alpha-1(XI) chain; collagen type XI alpha 1 chain; collagen XI, alpha-1 polypeptide; collagen, type XI, alpha 1; pro-alpha1(XI) collagen; procollagen, type XI, alpha 1; STL2; STL3; XI chain precursor
• Gene Symbols: COL11A1
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to amino acids 571-620 of human COL11A1.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12814, 1301
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG