COL11A2 Monoclonal Antibody (GT473), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA527738

Catalog No. PIMA527738

Description

Positive Control: human COL11A2-transfected 293T cells (N-terminal fragment of COL11A2 isoform 1) Predicted Reactivity: Mouse (85%), Rat (85%), Bovine (93%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.

Specifications

• Antigen: COL11A2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P13942, Q64739
• Gene Symbols: COL11A2
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human COL11A2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Western Blot
• Clone: GT473
• Conjugate: Unconjugated
• Gene: COL11A2
• Gene Alias: COL11A2; Collagen alpha-2(XI) chain; collagen type XI alpha 2; collagen type XI alpha 2 chain; collagen XI-like; collagen, type XI, alpha 2; DAQB-79P13.8; DFNA13; DFNB53; FBCG2; HGNC:2187; HKE5; PARP; pro-a2 chain of collagen type XI; procollagen, type XI, alpha 2; putative collagen XI; STL3; type XI collagen alpha2 chain
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 12815, 1302, 294279
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid