Invitrogen™ COL17A1 Recombinant Rabbit Monoclonal Antibody (8W2C8)

Catalog No.	Quantity
PIMA535582	100 μL

Catalog No. PIMA535582

Supplier: Invitrogen™ MA535582

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: SVRRGSSYSS SMSTGGGGAG SLGAGGAFGE AAGDRGPYGT DIGPGGGYGA AAEGGMYAGN GGLLGADFAG DLDYNELAVR VSESMQRQGL LQGMAYTVQG P.

COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein, and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. COL17A1 is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Moreover, COL17A1 is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.

Specifications

• Antigen: COL17A1
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: 8W2C8
• Concentration: 1.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: COL17A1
• Gene Accession No.: Q9UMD9
• Gene Alias: 120 kDa linear IgA dermatosis antigen; 120 kDa linear IgA disease antigen; 120 kDa linear IgA disease antigen homolog; 180 kDa bullous pemphigoid antigen 2; 97 kDa LAD antigen; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa linear IgA disease antigen; alpha 1 type XVII collagen; BA16H23.2; bA16H23.2 (collagen, type XVII, alpha 1 (BP180)); BP180; BPA-2; Bpag; BPAG2; Bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); Col17a1; Collagen alpha-1(XVII) chain; collagen type XVII alpha 1; collagen XVII, alpha-1 polypeptide; collagen, type XVII, alpha 1; ERED; LABD97; LAD-1; Linear IgA bullous disease antigen of 97 kDa; Linear IgA disease antigen 1; procollagen, type XVII, alpha 1; type XVII collagen alpha-1
• Gene Symbols: COL17A1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1300-1400 of human Collagen XVII/COL17A1 (Q9UMD9).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1308
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG