Invitrogen™ COL17A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560461

Catalog No. PIPA560461

Description

Immunogen sequence: DGTEVTERIV TETVTTRLTS LPPKGGTSNG YAKTASLGGG SRLEKQSLTH GSSGYINSTG STRGHASTSS YRRAHSPAST LPNSPGSTFE RKTHVTR Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein, and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. COL17A1 is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Moreover, COL17A1 is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.

Specifications

• Antigen: COL17A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COL17A1
• Gene Alias: 120 kDa linear IgA dermatosis antigen; 120 kDa linear IgA disease antigen; 120 kDa linear IgA disease antigen homolog; 180 kDa bullous pemphigoid antigen 2; 97 kDa LAD antigen; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa linear IgA disease antigen; alpha 1 type XVII collagen; BA16H23.2; bA16H23.2 (collagen, type XVII, alpha 1 (BP180)); BP180; BPA-2; Bpag; BPAG2; Bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); Col17a1; Collagen alpha-1(XVII) chain; collagen type XVII alpha 1; collagen XVII, alpha-1 polypeptide; collagen, type XVII, alpha 1; ERED; LABD97; LAD-1; Linear IgA bullous disease antigen of 97 kDa; Linear IgA disease antigen 1; procollagen, type XVII, alpha 1; type XVII collagen alpha-1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1308
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UMD9
• Gene Symbols: COL17A1
• Immunogen: Recombinant protein corresponding to Human COL17A1. Recombinant protein control fragment (Product #RP-100377).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG