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Invitrogen™ COL17A1 Recombinant Rabbit Monoclonal Antibody (2C3)
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Catalog No. PIMA524848
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PIMA524848 100 μL
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Catalog No. PIMA524848 Supplier Invitrogen™ Supplier No. MA524848
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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein, and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. COL17A1 is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Moreover, COL17A1 is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen COL17A1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 2C3
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene COL17A1
Gene Accession No. Q07563, Q9UMD9
Gene Alias 120 kDa linear IgA dermatosis antigen; 120 kDa linear IgA disease antigen; 120 kDa linear IgA disease antigen homolog; 180 kDa bullous pemphigoid antigen 2; 97 kDa LAD antigen; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa linear IgA disease antigen; alpha 1 type XVII collagen; BA16H23.2; bA16H23.2 (collagen, type XVII, alpha 1 (BP180)); BP180; BPA-2; Bpag; BPAG2; Bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); Col17a1; Collagen alpha-1(XVII) chain; collagen type XVII alpha 1; collagen XVII, alpha-1 polypeptide; collagen, type XVII, alpha 1; ERED; LABD97; LAD-1; Linear IgA bullous disease antigen of 97 kDa; Linear IgA disease antigen 1; procollagen, type XVII, alpha 1; type XVII collagen alpha-1
Gene Symbols COL17A1
Host Species Rabbit
Immunogen Recombinant COL17A1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12821, 1308, 294027
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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