Invitrogen™ COL1A2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5144956

Catalog No. FEPA5144956

Description

Immunogen sequence: IKVYCDFSTG ETCIRAQPEN IPAKNWYRSS KDKKHVWLGE TINAGSQFEY NVEGVTSKEM ATQLAFMRLL ANYAS Antigen sequence identity: Mouse 83%; Rat 81%.

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Specifications

• Antigen: COL1A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COL1A2
• Gene Alias: AA960264; AI325291; alpha 2 type I procollagen; alpha 2(I) collagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha2 chain of type I collagen; alpha-2 type I collagen; alpha-2(1) collagen; COL1; COL1A2; Col1a-2; COLA; Cola2; Cola-2; collagen; collagen a2; collagen alpha 2(I) chain precursor; collagen alpha-2; collagen alpha-2 chain precursor; collagen alpha-2(I) chain; collagen COL1A2; Collagen I; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 2 chain; collagen, type I, alpha 2; OI4; oim; osteogenesis imperfecta; precollagen alpha-2; procollagen, type I, alpha 2; type I collagen alpha-2 chain; type I procollagen
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1278
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Isotype: IgG

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P08123
• Gene Symbols: COL1A2
• Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 1191-1265.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Format: Liquid