Invitrogen™ COL1A2 Polyclonal Antibody

Catalog No.	Quantity
PA550938	100 μL

Catalog No. PA550938 Supplier Invitrogen™ Supplier No. PA550938

Description

Rabbit Polyclonal Antibody

COL1A2 Polyclonal Antibody detects endogenous levels of COL1A2 protein.

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Specifications

• Antigen: COL1A2
• Applications: ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: COL1A2
• Gene Accession No.: P02466, P08123, Q01149
• Gene Alias: AA960264; AI325291; alpha 2 type I procollagen; alpha 2(I) collagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha2 chain of type I collagen; alpha-2 type I collagen; alpha-2(1) collagen; COL1; COL1A2; Col1a-2; COLA; Cola2; Cola-2; collagen; collagen a2; collagen alpha 2(I) chain precursor; collagen alpha-2; collagen alpha-2 chain precursor; collagen alpha-2(I) chain; collagen COL1A2; Collagen I; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 2 chain; collagen, type I, alpha 2; OI4; oim; osteogenesis imperfecta; precollagen alpha-2; procollagen, type I, alpha 2; type I collagen alpha-2 chain; type I procollagen
• Gene Symbols: COL1A2
• Host Species: Rabbit
• Immunogen: Synthesized peptide derived from the N-terminal region of human COL1A2.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1278, 12843, 84352
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG