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Invitrogen™ COL1A2 Polyclonal Antibody
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Catalog No. PIPA5120479
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PIPA5120479 100 μL
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Catalog No. PIPA5120479 Supplier Invitrogen™ Supplier No. PA5120479
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Description

Rabbit Polyclonal Antibody

Positive test controls include: Rat skeletal muscle, Rat skin. The target is usually found in the following locations: Secreted, extracellular matrix, extracellular space. Immunogen sequence: RTCRDLRLSH PEWSSGYYWI DPNQGCTMDA IKVYCDFSTG ETCIRAQPEN IPAKNWYRSS KDKKHVWLGE TINAGSQFEY NVEGVTSKEM ATQLAFMRLL.

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen COL1A2
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene COL1A2
Gene Accession No. P02466, P08123, Q01149
Gene Alias AA960264; AI325291; alpha 2 type I procollagen; alpha 2(I) collagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha2 chain of type I collagen; alpha-2 type I collagen; alpha-2(1) collagen; COL1; COL1A2; Col1a-2; COLA; Cola2; Cola-2; collagen; collagen a2; collagen alpha 2(I) chain precursor; collagen alpha-2; collagen alpha-2 chain precursor; collagen alpha-2(I) chain; collagen COL1A2; Collagen I; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 2 chain; collagen, type I, alpha 2; OI4; oim; osteogenesis imperfecta; precollagen alpha-2; procollagen, type I, alpha 2; type I collagen alpha-2 chain; type I procollagen
Gene Symbols COL1A2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1161-1260 of human Collagen I/COL1A2 (NP_0000802).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1278, 12843, 84352
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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