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Invitrogen™ COL4A3 Polyclonal Antibody
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Catalog No. FEPA5144090
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100 μg
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FEPA5144090 100 μg
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Catalog No. FEPA5144090 Supplier Invitrogen™ Supplier No. PA5144090
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Description

Rabbit Polyclonal Antibody

COL4A3 Polyclonal Antibody for IHC (P), ELISA

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010].
TRUSTED_SUSTAINABILITY

Specifications

Antigen COL4A3
Applications ELISA, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
Gene COL4A3
Gene Accession No. Q01955
Gene Alias COL4A3; collagen alpha-3; Collagen alpha-3(IV) chain; collagen IV, alpha-3 polypeptide; collagen type IV alpha 3 chain; collagen, type IV, alpha 3 (Goodpasture antigen); Goodpasture antigen; IV chain; Tumstatin
Gene Symbols COL4A3
Host Species Rabbit
Immunogen Recombinant Human Collagen alpha-3(IV) chain protein (1427-1668AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1285
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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