Invitrogen™ COL4A5 Polyclonal Antibody

Catalog No.	Quantity
PIPA5121239	100 μL

Catalog No. PIPA5121239 Supplier Invitrogen™ Supplier No. PA5121239

Description

Rabbit Polyclonal Antibody

Positive test controls include: 22Rv1, NCI-H460, HepG2. The target is usually found in the following locations: Secreted, basement membrane, extracellular matrix, extracellular space. Immunogen sequence: SSVAHGFLIT RHSQTTDAPQ CPQGTLQVYE GFSLLYVQGN KRAHGQDLGT AGSCLRRFST MPFMFCNINN VCNFASRNDY SYWLSTPEPM PMSMQPLKGQ SIQPFISRCA VCEAPAVVIA VHSQTIQIPH CPQGWDSLWI GYSFMMHTSA GAEGSGQALA SPGSCLEEFR SAPFIECHGR GTCNYYANSY SFWLATVDVS DMFSKPQSET LKAGDLRTRI SRCQVCMKRT.

Collagens are highly conserved and are characterized by an uninterrupted Glycine-X-Y triplet repeat. Col1, the fibrillar collagen found in most connective tissues, is the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Col2, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia. Col3 is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome type IV, aortic and arterial aneurysms. Col4 is a major consitiuent of the basement membranes along with laminins and enactins. It is composed of alpha 1 IV chain and alpha 2 IV chain in 2:1 ratio. Col4 antibodies are useful in detecting the loss of parts of basement membrane in carcinomas. Col5 is found in tissues containing Col1 and appears to regulate the assembly of heterotypic fibers composed of both Col1 and Col5. Col5 is closely related to type XI collagen; mutations in this gene are associated with Ehlers-Danlos syndrome.

Specifications

• Antigen: COL4A5
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: COL4A5
• Gene Accession No.: P29400
• Gene Alias: ASLN; ATS; CA54; CO4A5; COL4A5; Collagen alpha-5(IV) chain; collagen IV, alpha-5 polypeptide; collagen of basement membrane, alpha-5 chain; collagen type IV alpha 5 chain; collagen type IV alpha5 chain; collagen, type IV, alpha 5; dA149D17.3; dA24A23.1; procollagen type IV alpha 5; procollagen, type IV, alpha 5
• Gene Symbols: COL4A5
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1462-1691 of human COL4A5 (NP_203699.1).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1287
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG