Collagen I Recombinant Rabbit Monoclonal Antibody (ST58-04), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Supplier:  Thermo Scientific MA532178

Catalog No. PIMA532178

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.

Specifications

• Antigen: Collagen I
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
• Gene Accession No.: P02452, P02453, P02465, P08123
• Gene Symbols: COL1A1, COL1A2
• Immunogen: Synthetic peptide within Human COL1A1 aa 1191-1238
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry, Western Blot
• Clone: ST58-04
• Conjugate: Unconjugated
• Gene: COL1A2
• Gene Alias: AA960264, AI325291, alpha 1 type I collagen, alpha 2 type I collagen, alpha 2 type I procollagen, alpha 2(I) collagen, alpha 2(I) procollagen, alpha 2(I)-collagen, alpha1 chain of type I collagen, alpha-1 collagen (I), alpha-1 type 1 collagen, alpha-1 type I collagen, alpha-1 type-1 collagen, alpha1(I) procollagen, alpha2 chain of type I collagen, alpha-2 type I collagen, alpha-2(1) collagen, alpha2(I) collagen, COL1, Col1a1, Col1a-1, COL1A1, matrix protein, Col1a2, Col1a-2, COLA, Cola1, Cola-1, Cola2, Cola-2, COLIA1, collagen, collagen 1 alpha 2 chain, collagen a2, collagen alpha 1 chain type I, collagen alpha 2(I) chain precursor, collagen alpha-1 chain, collagen alpha-1 chain precursor, collagen alpha-1(I) chain, collagen alpha-1(I) chain preproprotein, collagen alpha-2, collagen alpha-2 chain precursor, collagen alpha-2(I) chain, collagen COL1A2, collagen I alpha-2 polypeptide, collagen I, alpha-2 polypeptide, collagen of skin, tendon and bone, alpha-1 chain, collagen of skin, tendon and bone, alpha-2 chain, collagen type I alpha 1, collagen type I alpha 1 chain, collagen type I alpha 2 chain, collagen, type 1, alpha 1, collagen, type I, alpha 1, collagen, type I, alpha 2, EDSC, Mov13, Mov-13, OI1, OI2, OI3, OI4, oim, osteogenesis imperfecta, precollagen alpha-2, prepro-alpha-1 collagen type I, pro-alpha-1 collagen type 1, procollagen type I, alpha 1, procollagen, type 1, alpha 1, procollagen, type I, alpha 1, procollagen, type I, alpha 2, similar to pro alpha 1(I) collagen, Type I Collagen, type I collagen alpha 1 chain, type I collagen alpha1, type I collagen alpha-2 chain, type I collagen pre-pro-alpha1(I) chain, type I proalpha 1, type I procollagen, type I procollagen alpha 1 chain, type I-alpha 1 collagen
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1277, 1278, 282187, 282188
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid