Invitrogen™ COLQ Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530941

Catalog No. PIPA530941

Description

Recommended positive controls: HepG2. Predicted reactivity: Mouse (87%), Rat (82%), Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

COLQ (collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase), also known as EAD, is a 455 amino acid protein that localizes to the end plate of skeletal muscle. COLQ anchors the catalytic subunits of asymmetric AChE (acetylcholinesterase) to the basal lamina at the neuromuscular junctions of vertebrates. Mutations of COLQ lead to congenital myasthenic syndromes which are rare autosomal recessive diseases characterized by general weakness increased by exertion, ophthalmoplegia and refractoriness to anticholinesterase drugs. Eight isoforms exist due to alternative splicing events.

Specifications

• Antigen: COLQ
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COLQ
• Gene Alias: A130034K24Rik; acetylcholinesterase collagenic tail peptide; Acetylcholinesterase-associated collagen; AChE Q subunit; CMS5; collagen like tail subunit of asymmetric acetylcholinesterase; collagenic tail of endplate acetylcholinesterase; collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase; collagen-like tail subunit of asymmetric acetylcholinesterase; Colq; EAD; single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8292
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9Y215
• Gene Symbols: COLQ
• Immunogen: Recombinant protein encompassing a sequence within the center region of human COLQ. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG