Invitrogen™ COMMD10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5140077

Catalog No. PIPA5140077

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: SLEKQDLHLV LETISFILEQ AVYHNVKPAA LQQQLENIHL RQDKAEAFVN TWSSMGQ.

The COMMD family represents a group of evolutionary conserved proteins that share a common COMM domain at their extreme C-terminus, which provides an interface for protein-protein interactions. COMMD10 (COMM domain containing 10), also known as PTD002 or HSPC305, is a 202 amino acid protein that belongs to the COMMD family and contains one COMM domain. The gene encoding COMMD10 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B.

Specifications

• Antigen: COMMD10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COMMD10
• Gene Alias: 2310003A05Rik; AU019438; COMM domain containing 10; COMM domain-containing protein 10; COMMD10; Down-regulated in W/WV mouse stomach 2; DRWMS2; HSPC305; mDRWMS2; PTD002
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51397
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6G5
• Gene Symbols: COMMD10
• Immunogen: Recombinant protein corresponding to Human COMMD10. Recombinant protein control fragment (Product #RP-108056).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG