Invitrogen™ Complement C4b Polyclonal Antibody

Chicken Polyclonal Antibody

Supplier:  Invitrogen™ PA19534

Catalog No. 01-674-417

Description

PA1-9534 detects C4b complement in human samples. PA1-9534 has been successfully used in Western blot and ELISA procedures. By Western blot, PA1-9534 detects a 88 Kda, 75 Kda, 33 Kda protein representing C4b complement. PA1-9534 immunogen is a purified human C4b complement protein. Store product at 4ºC for up to one week and -20ºC for long-term.

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

Specifications

• Antigen: Complement C4b
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C4B
• Gene Alias: Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A; C4a anaphylatoxin; C4A13; C4A91; C4B; C4B_2; C4B1; C4B12; C4B2; C4B3; C4B5; C4b-A; C4b-B; C4BD; C4d-A; C4d-B; C4F; CH; Chido form of C4; CO4; Complement C4 beta chain; Complement C4 gamma chain; Complement C4-A; Complement C4-A alpha chain; Complement C4-B; Complement C4-B alpha chain; complement C4B1a; complement C4-B-like; complement component 4B (Chido blood group); complement component 4B (Chido blood group), copy 2; CPAMD2; CPAMD3; DADB-112B14.11; FLJ60561; MGC164979
• Host Species: Chicken
• Purification Method: IgY fraction
• Regulatory Status: RUO
• Gene ID (Entrez): 100293534, 721
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P0C0L5
• Gene Symbols: C4B, C4B_2
• Immunogen: Purified human C4b complement protein.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgY

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov