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Invitrogen™ Complement C4b Polyclonal Antibody, Invitrogen™

Catalog No. FEPA5145312
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200 μL
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FEPA5145312 20 μL
FEPA5145311 200 μL
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Catalog No. FEPA5145312 Supplier Invitrogen™ Supplier No. PA5145312
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Description

Rabbit Polyclonal Antibody

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Complement C4b
Applications Immunohistochemistry (Paraffin), Western Blot, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
Gene C4B
Gene Accession No. P01029, P0C0L5
Gene Alias Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A; C4a anaphylatoxin; C4A13; C4A91; C4B; C4B_2; C4B1; C4B12; C4B2; C4B3; C4B5; C4b-A; C4b-B; C4BD; C4d-A; C4d-B; C4F; CH; Chido form of C4; CO4; Complement C4 beta chain; Complement C4 gamma chain; Complement C4-A; Complement C4-A alpha chain; Complement C4-B; Complement C4-B alpha chain; complement C4B1a; complement C4-B-like; complement component 4B (Chido blood group); complement component 4B (Chido blood group), copy 2; CPAMD2; CPAMD3; DADB-112B14.11; FLJ60561; MGC164979
Gene Symbols C4B, C4B_2
Host Species Rabbit
Immunogen Recombinant Mouse C4B protein, Gln126-Ser366 (Accession #P01029).
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100293534, 12268, 721
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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