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Invitrogen™ Complement C5a Monoclonal Antibody (C17/5)
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Catalog No. GAU0250502
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400 μL
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Catalog No. Quantity
GAU0250502 400 μL
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Catalog No. GAU0250502 Supplier Invitrogen™ Supplier No. GAU0250502
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Description

Mouse Monoclonal Antibody

Specificity: GAU 025-05 reacts with human C5a/C5a (desArg) and cross-reacts with baboon C5a/C5a (desArg). Reactivity: For ELISA applications, recombinant C5a coated onto a microtiter well results in a strong reaction. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Complement C5a
Applications ELISA, Western Blot
Classification Monoclonal
Clone C17/5
Concentration 1.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene C5
Gene Accession No. P01031
Gene Alias anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C4B1; C4B12; C4B2; C4B3; C4B5; C4F; C5; C5a; C5a anaphylatoxin; C5b; C5D; CH; CO4; complement C5; Complement C5 alpha chain; Complement C5 alpha' chain; Complement C5 beta chain; complement component 5; CPAMD3; CPAMD4; DADB-112B14.11; ECLZB; FLJ17816; FLJ17822; FLJ60561; Hc; He; Hemolytic complement; MGC142298; MGC164979; prepro-C5; RGD1561905
Gene Symbols C5
Host Species Mouse
Immunogen Purified human C5a.
Purification Method Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 727
Target Species Human, Monkey
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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