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Invitrogen™ Complement C9 Monoclonal Antibody (X197)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA140186
Description
MA1-40186 detects C9 from human samples. MA1-40186 has been successfully used in flow cytometry, ELISA, functional assays, Western blot, and immunohistochemistry (paraffin and frozen) applications. The MA1-40186 immunogen is the C-terminal region of human C9. Endotoxin <24 EU/mg.
C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.
Specifications
Complement C9 | |
Monoclonal | |
0.1 mg/mL | |
PBS with 0.1% BSA and no preservative | |
P02748 | |
C9 | |
Human C9. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot | |
X197 | |
Unconjugated | |
C9 | |
ARMD15; C9; C9D; complement C9; complement component 9; complement component C9; Complement component C9a; Complement component C9b; complement protein C9; complement protein C9 precursor | |
Mouse | |
Protein G | |
RUO | |
735 | |
4°C | |
Liquid |
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