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Invitrogen™ Complement C9 Monoclonal Antibody (X197)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA140186

Catalog No. 01-676-547


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Description

Description

MA1-40186 detects C9 from human samples. MA1-40186 has been successfully used in flow cytometry, ELISA, functional assays, Western blot, and immunohistochemistry (paraffin and frozen) applications. The MA1-40186 immunogen is the C-terminal region of human C9. Endotoxin <24 EU/mg.

C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Complement C9
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and no preservative
P02748
C9
Human C9.
100 μg
Primary
Human
Antibody
IgG1
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
X197
Unconjugated
C9
ARMD15; C9; C9D; complement C9; complement component 9; complement component C9; Complement component C9a; Complement component C9b; complement protein C9; complement protein C9 precursor
Mouse
Protein G
RUO
735
4°C
Liquid
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