Invitrogen™ Complement C9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596370

Catalog No. PIPA596370

Description

Immunogen sequence: QYTTSYDPEL TESSGSASHI DCRMSPWSEW SQCDPCLRQM FRSRSIEVFG QFNGKRCTDA VGDRRQCVPT EPCEDAEDDC GNDFQCSTGR CIKMRLRCNG DNDCGDFSDE DDCESEPRPP CRDRVVEESE LARTAGYGIN ILGMDPLSTP FDNEFYNGLC NRDRDGNTLT YYRRPWNVAS LIYETKGEKN FRTEHYEEQI EAFKSIIQEK TSNFNAAISL KFTPTETNKA EQCCEETASS ISLH; Positive Samples: Mouse liver; Cellular Location: Cell membrane, Multi-pass membrane protein.

C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.

Specifications

• Antigen: Complement C9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C9
• Gene Alias: ARMD15; C9; C9D; complement C9; complement component 9; complement component C9; Complement component C9a; Complement component C9b; complement protein C9; complement protein C9 precursor
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12279, 735
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.29 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P02748, P06683
• Gene Symbols: C9
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-265 of human C9 (NP_0017281).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG