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Complement factor B Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501726078 Shop All Proteintech Group Inc Products
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Description

Rabbit Polyclonal Antibody

This antibody raised against 573-761aa of human complement factor B can recognize complement factor B and Bb fragment.

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5′ end of the gene for complement component 2.

Specifications

Antigen Complement factor B
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.14 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene CFB
Gene Accession No. P00751
Gene Alias BF, BFD, C3/C5 convertase, CFAB, CFB, Complement factor B, FB, FBI12, GBG, Glycine rich beta glycoprotein, H2 Bf, PBF2, Properdin factor B
Gene Symbols CFB
Host Species Rabbit
Immunogen Complement factor B Fusion Protein Ag0226
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 629
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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