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Invitrogen™ MTCO2 Monoclonal Antibody (4B12A5)
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Catalog No. 459150
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Catalog No. Quantity
45-915-0 100 μg
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Catalog No. 45-915-0 Supplier Invitrogen™ Supplier No. 459150
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Description

Mouse Monoclonal Antibody

Positive control: Mitochondria from yeast membrane extract.

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen MTCO2
Applications Western Blot
Classification Monoclonal
Clone 4B12A5
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation HEPES buffered saline with 0.02% sodium azide
Gene COX2
Gene Accession No. P00410
Gene Alias ACI60_gp02; Co2; COII; COX2; COXII; cyclooxygenase; cytchrome c oxidase sububnit 2; Cytochrome c oxidase polypeptide II; Cytochrome c oxidase subunit 2; cytochrome c oxidase subunit II; mitochondrially encoded cytochrome c oxidase II; Mtco2; MT-CO2; OXI1; OXII; Q0250
Gene Symbols COX2
Host Species Mouse
Immunogen Full length purified native protein.
Purification Method IgG fraction
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24573139, 854622
Target Species Yeast
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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