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Invitrogen™ MTCO2 Monoclonal Antibody (4B12A5)

Mouse Monoclonal Antibody
Supplier: Invitrogen™ 459150

Description
Positive control: Mitochondria from yeast membrane extract.
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [UniProt].
Specifications
MTCO2 | |
Monoclonal | |
1 mg/mL | |
HEPES buffered saline with 0.02% sodium azide | |
P00410 | |
COX2 | |
Full length purified native protein. | |
100 μg | |
Primary | |
Yeast | |
Antibody | |
IgG2a κ |
Western Blot | |
4B12A5 | |
Unconjugated | |
COX2 | |
ACI60_gp02; Co2; COII; COX2; COXII; cyclooxygenase; cytchrome c oxidase sububnit 2; Cytochrome c oxidase polypeptide II; Cytochrome c oxidase subunit 2; cytochrome c oxidase subunit II; mitochondrially encoded cytochrome c oxidase II; Mtco2; MT-CO2; OXI1; OXII; Q0250 | |
Mouse | |
IgG fraction | |
RUO | |
24573139, 854622 | |
4°C, do not freeze | |
Liquid |
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