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Invitrogen™ COMT Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA577920

Catalog No. PIPA577920


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Description

Description

Positive Control: Molt-4, mouse spleen Predicted Reactivity: Rat (82%), Dog (81%), Pig (82%), Rhesus Monkey (93%), Bovine (81%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

COMT
Polyclonal
Unconjugated
Comt
Catechol O-methyltransferase; catecholamine-O-methyltransferase; catechol-O-methyltransferase; catechol-O-methyltransferase 1; catechol-O-methyltransferase isoform; Comt; Comt1; D16Wsu103e; D330014B15Rik; epididymis secretory sperm binding protein Li 98n; HEL-S-98n; OTTHUMP00000197749; OTTHUMP00000197750; testicular tissue protein Li 42
Rabbit
Antigen affinity chromatography
RUO
12846, 1312
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
ELISA, Immunohistochemistry (Paraffin), Western Blot
0.32 mg/mL
0.1M tris glycine with 10% glycerol, 0.1M glycine and 0.01% thimerosal; pH 7
O88587, P21964
Comt
Recombinant protein encompassing a sequence within the center region of human COMT. The exact sequence is proprietary.
100 μL
Primary
Human, Mouse
Antibody
IgG
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