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Invitrogen™ COMT Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119011

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Catalog No. PIPA5119011


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Description

Description

COMT Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

COMT
Polyclonal
Unconjugated
Comt
Catechol O-methyltransferase; catecholamine-O-methyltransferase; catechol-O-methyltransferase; catechol-O-methyltransferase 1; catechol-O-methyltransferase isoform; Comt; Comt1; D16Wsu103e; D330014B15Rik; epididymis secretory sperm binding protein Li 98n; HEL-S-98n; OTTHUMP00000197749; OTTHUMP00000197750; testicular tissue protein Li 42
Rabbit
Antigen affinity chromatography
RUO
1312
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
500 μg/mL
PBS with 50% glycerol and 0.05% ProClin 300
P21964
Comt
Recombinant protein Catechol-O-Methyltransferase. The antigen corresponds to amino acid range 52-271 of the target protein.
200 μL
Primary
Human
Antibody
IgG
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