COMT Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PIPA588877	100 μL

Catalog No. PIPA588877 Supplier Thermo Scientific Supplier No. PA588877

Description

Rabbit Polyclonal Antibody

Immunogen sequence: VGDKKGKIVD AVIQEHQPSV LLELGAYCGY SAVRMARLLS PGARLITIEI NPDCAAITQR MVDFAGVKDK VTLVVGASQD IIPQLKKKYD VDTLDMVFLD HWKDRYLPDT LLLEECGLLR KGTVLLADNV ICPGAPDFLA HVRGSSCFEC THYQSFLEYR EVVDGLEKAI YKGPGSEAGP; Positive Samples: MCF-7, HT-29, THP-1, A-431, HepG2, Mouse liver; Cellular Location: Cell membrane, Cytoplasm, Extracellular side, Single-pass type II membrane protein

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Specifications

• Antigen: COMT
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.43 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene: Comt
• Gene Accession No.: O88587, P21964
• Gene Alias: Catechol O-methyltransferase, catecholamine-O-methyltransferase, catechol-O-methyltransferase, catechol-O-methyltransferase 1, catechol-O-methyltransferase isoform, Comt, Comt1, D16Wsu103e, D330014B15Rik, epididymis secretory sperm binding protein Li 98n, HEL-S-98n, OTTHUMP00000197749, OTTHUMP00000197750, testicular tissue protein Li 42
• Gene Symbols: Comt
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT (NP_0092941)
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12846, 1312
• Target Species: Human, Mouse
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG