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Invitrogen™ COMT Recombinant Rabbit Monoclonal Antibody (JG39-48)
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Catalog No. PIMA534798
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PIMA534798 100 μL
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Catalog No. PIMA534798 Supplier Invitrogen™ Supplier No. MA534798
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: MCF-7, rat testis tissue lysate, mouse testis tissue.

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
TRUSTED_SUSTAINABILITY

Specifications

Antigen COMT
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone JG39-48
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Comt
Gene Accession No. P21964
Gene Alias Catechol O-methyltransferase; catecholamine-O-methyltransferase; catechol-O-methyltransferase; catechol-O-methyltransferase 1; catechol-O-methyltransferase isoform; Comt; Comt1; D16Wsu103e; D330014B15Rik; epididymis secretory sperm binding protein Li 98n; HEL-S-98n; OTTHUMP00000197749; OTTHUMP00000197750; testicular tissue protein Li 42
Gene Symbols Comt
Host Species Rabbit
Immunogen Recombinant protein within COMT aa 11-107.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1312
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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