Invitrogen™ Connexin 26 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518618

Catalog No. PIPA518618

Description

This antibody is predicted to react with human and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variables (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

Specifications

• Antigen: Connexin 26
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gjb2
• Gene Alias: AI325222; Cnx26; connexin 26; connexin-26; CX26; CXN-26; DFNA3; DFNA3A; DFNB1; DFNB1A; Gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2; gap junction protein beta 2; gap junction protein, beta 2; gap junction protein, beta 2, 26kDa; GJB2; Gjb-2; HID; KID; mutant gap junction protein beta 2; NSRD1; PPK
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 14619, 2706, 394266
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P21994, P29033, Q00977
• Gene Symbols: Gjb2
• Immunogen: Synthetic peptide sequence (YLLIRYCSGKSKKP) corresponding to the C-terminus amino acids of GJB2 (aa 212-225).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG