Invitrogen™ Connexin 26 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 512800

Catalog No. 51-280-0

Description

Connexin 26 Polyclonal Antibody for Western Blot, ICC/IF, IHC (F), IHC (P), ELISA

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variables (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

Specifications

• Antigen: Connexin 26
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gjb2
• Gene Alias: AI325222; Cnx26; connexin 26; connexin-26; CX26; CXN-26; DFNA3; DFNA3A; DFNB1; DFNB1A; Gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2; gap junction protein beta 2; gap junction protein, beta 2; gap junction protein, beta 2, 26kDa; GJB2; Gjb-2; HID; KID; mutant gap junction protein beta 2; NSRD1; PPK
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14619, 2706, 394266
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: P21994, P29033, Q00977
• Gene Symbols: Gjb2
• Immunogen: A 13 amino acid synthetic peptide derived from the C-terminus of the mouse Connexin 26 protein. This mouse sequence differs from the rat sequence by a single amino acid and from the human sequence by two (non-consecutive) amino acids.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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