Invitrogen™ Connexin 30 Polyclonal Antibody (Z-PP9)

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 712200

Catalog No. 71-220-0

Description

This antibody is specific for the Connexin 30. Cross-reactivity with the highly related Connexin 26 protein or with other Connexin family members has not been detected. Reactivity of this antibody has been confirmed by western blotting using cell lysates derived from adult rat, mouse, human, and cat brains.

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.

Specifications

• Antigen: Connexin 30
• Classification: Polyclonal
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: O95452, P70689
• Gene Symbols: GJB6
• Immunogen: A synthetic peptide derived from the unique C-terminus of the mouse Connexin 30 protein.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Feline
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: Z-PP9
• Conjugate: Unconjugated
• Gene: GJB6
• Gene Alias: AA958971; connexin 30; connexin-30; CX30; Cxn-30; D14Bwg0506e; DFNA3; DFNA3B; DFNB1B; ECTD2; ectodermal dysplasia 2, hidrotic (Clouston syndrome); ED2; EDH; Gap junction beta-6 protein; gap junction membrane channel protein beta 6; gap junction protein beta 6; gap junction protein, beta 6; gap junction protein, beta 6 (connexin 30); gap junction protein, beta 6, 30kDa; Gjb6; HED; HED2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101082796, 10804, 14623, 84403
• Content And Storage: -20°C
• Form: Liquid

Safety and Handling

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