Invitrogen™ Connexin 31.1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575619

Catalog No. PIPA575619

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.1, Cx31.1 or Gap junction beta-5 protein, is a 271 amino acid protein that is predominantly expressed in skin with lower expression in testis. Expression of connexin 31.1 is required for normal placental development in mice. Down-regulation of the connexin 31.1 gene correlates with head and neck squamous cell carcinomas (HNSCC) and therefore it may be a potential therapeutic target.

Specifications

• Antigen: Connexin 31.1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gjb5
• Gene Alias: Cnx31.1; connexin 31.1; connexin-31.1; Cx31.1; Cxn-31.1; Gap junction beta-5 protein; gap junction membrane channel protein beta 5; gap junction protein beta 5; gap junction protein, beta 5; gap junction protein, beta 5 (connexin 31.1); gap junction protein, beta 5, 31.1kDa; gap junctional protein cx31.1; Gjb5; Gjb-5
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14622, 2709, 29586
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide; pH 7.2
• Gene Accession No.: O95377, P28232, Q02739
• Gene Symbols: Gjb5
• Immunogen: Synthetic peptide corresponding to residues in Human Connexin 31.1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG