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Invitrogen™ Connexin 31.1 Polyclonal Antibody
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Catalog No. PIPA5103852
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100 μL
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PIPA5103852 100 μL
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Catalog No. PIPA5103852 Supplier Invitrogen™ Supplier No. PA5103852
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GJB5.

The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.1, Cx31.1 or Gap junction beta-5 protein, is a 271 amino acid protein that is predominantly expressed in skin with lower expression in testis. Expression of connexin 31.1 is required for normal placental development in mice. Down-regulation of the connexin 31.1 gene correlates with head and neck squamous cell carcinomas (HNSCC) and therefore it may be a potential therapeutic target.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Connexin 31.1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Gjb5
Gene Accession No. O95377, P28232, Q02739
Gene Alias Cnx31.1; connexin 31.1; connexin-31.1; Cx31.1; Cxn-31.1; Gap junction beta-5 protein; gap junction membrane channel protein beta 5; gap junction protein beta 5; gap junction protein, beta 5; gap junction protein, beta 5 (connexin 31.1); gap junction protein, beta 5, 31.1kDa; gap junctional protein cx31.1; Gjb5; Gjb-5
Gene Symbols Gjb5
Host Species Rabbit
Immunogen A synthesized peptide derived from human GJB5(Accession O95377), corresponding to amino acid residues G233-L273.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14622, 2709, 29586
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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