Invitrogen™ Connexin 31.1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103852

Catalog No. PIPA5103852

Description

Antibody detects endogenous levels of total GJB5.

The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.1, Cx31.1 or Gap junction beta-5 protein, is a 271 amino acid protein that is predominantly expressed in skin with lower expression in testis. Expression of connexin 31.1 is required for normal placental development in mice. Down-regulation of the connexin 31.1 gene correlates with head and neck squamous cell carcinomas (HNSCC) and therefore it may be a potential therapeutic target.

Specifications

• Antigen: Connexin 31.1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gjb5
• Gene Alias: Cnx31.1; connexin 31.1; connexin-31.1; Cx31.1; Cxn-31.1; Gap junction beta-5 protein; gap junction membrane channel protein beta 5; gap junction protein beta 5; gap junction protein, beta 5; gap junction protein, beta 5 (connexin 31.1); gap junction protein, beta 5, 31.1kDa; gap junctional protein cx31.1; Gjb5; Gjb-5
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14622, 2709, 29586
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O95377, P28232, Q02739
• Gene Symbols: Gjb5
• Immunogen: A synthesized peptide derived from human GJB5(Accession O95377), corresponding to amino acid residues G233-L273.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG