Invitrogen™ Connexin 31 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 365100

Catalog No. 36-510-0

Description

This antibody reacts with the ~32 kDa mouse Connexin 31 on Western blots; the band observed at ~62 kDa is probably due to dimerization of Connexin 31. Several higher bands of unknown origin are observed in western blots of mouse skin homogenates.

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

Specifications

• Antigen: Connexin 31
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GJB3
• Gene Alias: Cnx31; connexin 31; connexin-31; Cx31; Cxn-31; D4Wsu144e; DFNA2; DFNA2B; EKV; Gap junction beta-3 protein; gap junction membrane channel protein beta 3; gap junction protein beta 3; gap junction protein, beta 3; gap junction protein, beta 3, 31kDa; Gjb3; Gjb-3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14620, 2707
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 1 month. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: O75712, P28231
• Gene Symbols: GJB3
• Immunogen: Synthetic peptide derived from the C-terminal region of mouse connexin 31 protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG