Invitrogen™ Contactin 2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552939

Catalog No. PIPA552939

Description

Immunogen sequence: RHFVSQTTGN LYIARTNASD LGNYSCLATS HMDFSTKSVF SKFAQLNLAA EDTRLFAPSI KARFPAETYA LVGQQVTLEC FAFGNPVPRI KWRKVDGSLS PQWTTAEPTL QIPSVSFEDE GTYECEAENS KGRDTVQ Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 98%.

Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.

Specifications

• Antigen: Contactin 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CNTN2
• Gene Alias: Axonal glycoprotein TAG-1; axonin; Axonin 1; Axonin1; axonin-1; axonin-1 cell adhesion molecule; AXT; Cntn2; contactin 2; contactin 2 (axonal); contactin 2 (transiently expressed); Contactin2; contactin-2; D130012K04Rik; DKFZp781D102; FAME5; MGC157722; TAG1; TAG-1; TAG-564; Tax; TAX1; TAX-1; transient axonal glycoprotein 1; transiently-expressed axonal glycoprotein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6900
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q02246
• Gene Symbols: CNTN2
• Immunogen: Recombinant protein corresponding to Human Contactin 2. Recombinant protein control fragment (Product #RP-94792).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG