Invitrogen™ COP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562890

Catalog No. PIPA562890

Description

Immunogen sequence: LHKGSLYPRI PGLGKELQTG THKLS Highest antigen sequence identity to the following orthologs: Mouse - 48%, Rat - 48%.

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. [UniProt].

Specifications

• Antigen: COP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CARD16
• Gene Alias: CARD only domain-containing protein 1; CARD only protein; CARD16; CARD-only protein 1; caspase recruitment domain family member 16; caspase recruitment domain family, member 16; caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; caspase-1 dominant-negative inhibitor pseudo-ICE; caspase-1 inhibitor COP; Constitutive photomorphogenesis protein 1 homolog; constitutive photomorphogenic protein 1; COP; COP1; E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase RFWD2; hCOP1; Pseudo interleukin-1 beta converting enzyme; pseudo interleukin-1beta converting enzyme; PSEUDO-ICE; pseudo-IL1B-converting enzyme; putative ubiquitin ligase COP1; RFWD2; ring finger and WD repeat domain 2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; RING finger and WD repeat domain protein 2; RING finger protein 200; RING-type E3 ubiquitin transferase RFWD2; RNF200
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114769
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5EG05
• Gene Symbols: CARD16
• Immunogen: Recombinant protein corresponding to Human COP1. Recombinant protein control fragment (Product #RP-101616).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG