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Invitrogen™ COPG Polyclonal Antibody
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Catalog No. PIPA587979
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100 μL
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PIPA587979 100 μL
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Catalog No. PIPA587979 Supplier Invitrogen™ Supplier No. PA587979
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IPGLERALQQ YTLEPSEKPF DLKSVPLATA PMAEQRTEST PITAVKQPEK VAATRQEIFQ EQLAAVPEFR GLGPLFKSSP EPVALTESET EYVIRCTKHT FTNHMVFQFD CTNTLNDQTL ENVTVQMEPT EAYEVLCYVP ARSLPYNQPG TCYTLVALPK EDPTAVACTF SCMMKFTVKD CDPTTGETDD EGYEDEYVLE DLEVTVADHI QKVMKLNFEA AWDEVGDEFE KEETFTLSTI KTLEEAVGNI VKFLGMHPCE RSDKVPDNKN THTLLLAGVF RGGHDILVRS RLLLLDTVTM QVTARSLEEL PVDIILASVG; Positive Samples: HepG2, A-375, BT-474, Mouse liver, Mouse kidney, Rat kidney; Cellular Location: COPI-coated vesicle membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Peripheral membrane protein.

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen COPG
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.12 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Copg1
Gene Accession No. Q4AEF8, Q9QZE5, Q9Y678
Gene Alias AU019265; BC056168; coat protein gamma-cop; coatomer protein complex subunit gamma 1; coatomer protein complex, subunit gamma 1; coatomer subunit gamma; coatomer subunit gamma-1; COPG; COPG1; D6Ertd71e; D6Wsu16e; Gamma-1-coat protein; gamma-1-COP; gamma-coat protein; gamma-COP
Gene Symbols Copg1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 555-874 of human COPG1 (NP_0572121).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22820, 297428, 54161
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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