Invitrogen™ COPG Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115041

Catalog No. PIPA5115041

Description

Antibody detects endogenous levels of total COPG.

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis. [UniProt].

Specifications

• Antigen: COPG
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Copg1
• Gene Alias: AU019265; BC056168; coat protein gamma-cop; coatomer protein complex subunit gamma 1; coatomer protein complex, subunit gamma 1; coatomer subunit gamma; coatomer subunit gamma-1; COPG; COPG1; D6Ertd71e; D6Wsu16e; Gamma-1-coat protein; gamma-1-COP; gamma-coat protein; gamma-COP
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22820, 297428, 54161
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q4AEF8, Q9QZE5, Q9Y678
• Gene Symbols: Copg1
• Immunogen: A synthesized peptide derived from human COPG1(Accession Q9Y678), corresponding to amino acid residues T718-M768.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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