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COPS7A Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988839
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50-198-8839 100 μL
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Catalog No. 50-198-8839 Supplier Bioss Supplier No. BS9124R
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Description

Rabbit Polyclonal Antibody

The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I B-alpha and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.

Specifications

Antigen COPS7A
Applications Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene COPS7A
Gene Accession No. Q9UBW8
Gene Alias COP9 (constitutive photomorphogenic) homolog, subunit 7a; COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana); COP9 (constitutive photomorphogenic), subunit 7a; COP9 complex S7a; COP9 complex subunit 7a; COP9 constitutive photomorphogenic homolog subunit 7A; COP9 signalosome complex subunit 7a; COP9 signalosome subunit 7A; COPS7A; CSN7; CSN7A; D6Ertd35e; Dermal papilla-derived protein 10; DERP10; JAB1-containing signalosome subunit 7a; SGN7a; signalosome subunit 7a
Gene Symbols COPS7A
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human COPS7A.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50813
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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