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COPS8/COP9 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

$395.30

Specifications

Antigen COPS8/COP9
Concentration 0.29 mg/mL
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate Unconjugated
Format Liquid
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-172-6014
Encompass_Preferred
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Proteintech Group IncSupplier Diversity Partner
100892AP150UL
150 μL
Each for $395.30
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Description

Description

COPS8 is a COP9 signalosome (CSN), which is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
Specifications

Specifications

COPS8/COP9
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Polyclonal
-20°C
0.29 mg/mL
Unconjugated
Rabbit
Human, Mouse
IgG
Antigen Affinity Chromatography
Antibody
SDS
Product Certifications
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