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Invitrogen™ COPS8 Polyclonal Antibody
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Catalog No. PIPA588736
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100 μL
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PIPA588736 100 μL
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Catalog No. PIPA588736 Supplier Invitrogen™ Supplier No. PA588736
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI PLSEPAPVPP IPNEQQLARL TDYVAFLEN; Positive Samples: U-87MG, A-375, HeLa, HepG2, Mouse brain, Mouse heart, Mouse liver, Mouse testis, Rat brain; Cellular Location: Cytoplasm, Nucleus.

COPS8 is a COP9 signalosome (CSN), which is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
TRUSTED_SUSTAINABILITY

Specifications

Antigen COPS8
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.11 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Cops8
Gene Accession No. Q6P4Z9, Q8VBV7, Q99627
Gene Alias 9430009J09Rik; AA408242; COP9; COP9 (constitutive photomorphogenic) homolog, subunit 8; COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana); COP9 constitutive photomorphogenic homolog subunit 8; COP9 homolog; COP9 signalosome complex subunit 8; COP9 signalosome subunit 8; COPS8; Csn8; hCOP9; JAB1-containing signalosome subunit 8; SGN8; signalosome subunit 8
Gene Symbols Cops8
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human COPS8 (NP_0067011).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 108679, 10920, 363283
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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