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Invitrogen™ Cortactin Polyclonal Antibody
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Catalog No. PIPA529799
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100 μL
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PIPA529799 100 μL
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Catalog No. PIPA529799 Supplier Invitrogen™ Supplier No. PA529799
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa, Neuro 2A, C8D30, NIH-3T3, C2C12, PC-12, Rat2, mouse brain, rat brain. Predicted reactivity: Mouse (98%), Rat (99%), Chicken (93%), Rhesus Monkey (100%), Bovine (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape. Cortactin also plays a role in the formation of lamellipodia and cell migration. It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells. Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cortactin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.28 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Cttn
Gene Accession No. Q14247, Q60598, Q66HL2
Gene Alias 1110020L01Rik; amplaxin; cortactin; Cttn; Cttnb; EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); FLJ34459; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); oncogene EMS1; Oncogene SRC8; Src substrate cortactin; src8; Unknown (protein for MGC:137923)
Gene Symbols Cttn
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Cortactin. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13043, 2017, 60465
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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