Invitrogen™ COX1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA131526

Catalog No. PIPA131526

Description

Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX22338-PEP).. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

Specifications

• Antigen: COX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTGS1
• Gene Alias: COI; COX1; Cox-1; COX3; Cox-3; COXI; cyclooxygenase 3; cyclooxygenase precursor (EC 1.14.99.1); cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; cytochrome c oxidase subunit I; mitochondrially encoded cytochrome c oxidase I; Mtco1; mt-Co1; P PGG/HS; PCOX1; PES-1; PGG/HS; PGH synthase 1; PGHS1; Pghs-1; PHS 1; PHS1; prostaglandin endoperoxide synthase; prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin G/H synthase precursor (EC 1.14.99.1); prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGHS; PTGS1; unnamed protein product
• Host Species: Goat
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19224, 4512, 5742
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P22437, P23219
• Gene Symbols: COX1, PTGS1
• Immunogen: Peptide with sequence QDDGPAVERPSTEL, from C Terminus of the protein sequence according to NP_000953; NP_542158.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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